We also repeated the analysis without the four best-known prognostic profiles (i.e. the Rotterdam 76-gene index [47], OncotypeDX RS [5], NKI-70-gene signature [3,4] and ROR-S [46]); in this secondary analysis, 31 of the 40 most frequently selected modules that built the previous combined models for ER-positive patients were again selected, including tumor size and grade (Additional File 2). This evidence concerns the gene ESR1 and neoplasm.