ESR1 and breast cancer: Among the modules and clinical variables selected to build the combined model, HER2 status, a module that tracks immune system response, cell proliferation (HS_Red1), and a module that tracks cell-adhesion/differentiation (HS_Red8) were associated with pCR (Figure 6b), while ER status and correlation to the Luminal A intrinsic breast cancer subtype centroid (Scorr_LumA) were associated with non-pCR.