Among the rest of the modules that frequently comprised the combined model for all patients, it is interesting to note that two of them were derived from a single study that evaluated the transcription factor E2F1-dependent gene expression program [22], two others were derived from predictions of β-catenin and MYC pathway deregulation in cancer cell lines [10], and another one was likely tracking stem cell-like biological processes [12]. The gene discussed is E2F1; the disease is cancer.