AFP and hepatocellular carcinoma: Using the transplant model in mice, where ACR dose-dependent reduction of serum levels of a tumor marker for HCC, α-fetoprotein (AFP) and the incidence of HCC (Additional file 7 Table S2), nuclear TG2 and CLSp1 increased in cancerous liver cells of ACR-treated nude mice transplanted with the JHH-7 cell line (Figure 4A, panels A and B, respectively) compared with adjacent normal liver (Figure 4A, panels D and E).