TGM2 and colon carcinoma: Whereas TG2 may be a substrate of caspase 3 during apoptosis of thymocytes, resulting in loss of transamidating function [25], TG2 in turn inhibits of apoptosis due to crosslinking and inactivation of caspase 3 in thapsigargin-mediated apoptosis of colon carcinoma cells [26].