Consistent with previous findings with another HCC cell line (HuH-7) [6], ACR treatment of JHH-7 cells, but not HC cells, suppressed phosphorylation of RXRα without affecting the expression of RXRα (Additional file 4 Figure S2A), prevented phospho-inactivation of RXRα, and enhanced the expression of TG2 (Additional file 4 Figure S2B). The gene discussed is RXRA; the disease is hepatocellular carcinoma.