SULF1 and cancer: Our luciferase reporter gene assay of rs2623047 G>A further showed that the G allele exhibited slightly higher promoter activity in SKOV-3 and HeLa cancer cell lines, which is consistent with one published study in which ovarian cancer patients with higher expression of SULF1 were more sensitive to platinum chemotherapy compared to others with lower SULF1 expression [15], suggesting that the G allele had a tumor suppression effect.