• The patient is suffering from pain with no analgesic therapy.• A patient with chronic heart failure due to left ventricular systolic dysfunction, without an ACE-inhibitor or an angiotensin receptor blocker.• A patient with atrial fibrillation without antithrombotic therapy.• Calcium and vitamin D supplements for a patient with osteoporosis who is already taking a bisphosphonate. Here, ACE is linked to osteoporosis.