Areas of interests are the critical involvement of WWOX/WOX1 in 1) apoptotic and stress responses in vivo and in vitro[1-3,7], 2) regulation of embryonic and tumor development and postnatal survival in vivo[6,7], 3) signaling and regulation of gene transcription [1-3,7], 4) normal physiology and metabolism [9-13], and 4) neural development, damage and degeneration (e.g. Alzheimer's disease) in vivo[14-19]. Here, WWOX is linked to early-onset autosomal dominant Alzheimer disease.