ZMPSTE24 and Hutchinson-Gilford progeria syndrome: Accordingly, it is tempting to speculate that the characteristic nuclear lamina abnormalities present in both HGPS and Zmpste24−/− cells induce -by a yet unknown mechanism- an upregulation of miR-1, which in turn leads to a reduction in Igf1 mRNA cellular content and finally, to a decrease in circulating IGF-1 (Figure 1).