The studies by Asakage T etal and Hiraki A et al [25,26] of Asian populations and risk of cancer of the upper aerodigestive tract, oral cavity, or oropharynx found a significant interaction between ALDH2*1/*2 genotype and heavy (p = 0·013) or moderate to heavy alcohol intake (p = 0·002). This evidence concerns the gene ALDH2 and cancer.