Bouchardy and colleagues[34] showed that in white populations, the highest risks of oral cavity or pharyngeal cancer were recorded for the heaviest drinkers, with a significant 7·2-times increased risk for carriers of CYP2E1 c2 and a significant 2·5-times increased risk for those of CYP2E1 c1/c1 genotype compared with moderate drinkers with c1/c1 genotype. Here, CYP2E1 is linked to pharynx cancer.