For oral, oropharyngeal, and hypopharynx cancers, the two [25,34] studies by Asakage T et al and Bouchardy C et al that we identified were inconsistent: in one study[34], the effects of ADH1C*1/*1 genotype and lifetime alcohol consumption in white individuals were associated with an increased risk; in another study [25], the risk of oral, oropharyngeal, or hypopharynx cancer were greater for Asians who were moderate to heavy drinkers and of genotype ADH1C*1/*2 or ADH1C*2/*2 than for Asians who were moderate to heavy drinkers with ADH1C*1/*1 genotype. This evidence concerns the gene ADH1C and hypopharynx cancer.