INS and diabetes mellitus: When investigated in all 5,702 treatment-naïve individuals (NGT, IFG, IGT, and screen-detected diabetics) the C-allele of rs2014355 associated with reduced serum insulin levels 30 minutes after an oral glucose load (β = -2.8% (-5.0%;-0.5%), P = 0.02), and reduced AUC for serum insulin of (β = -3.2% (-5.7%;-0.7%), P = 0.01).