Given the ample evidence for efficient TGF-β signaling and associated transcriptional responses in all melanoma cell lines tested thus far in our laboratory (see above and refs [35-37]), we tried to reproduce these data in the 1205Lu melanoma cell line, which is both highly invasive, strongly resistant to TGF-β growth inhibitory activity, capable of a strong SMAD3/4-specific transcriptional response to exogenous TGF-β stimulation, yet expresses high levels of SKI and SnoN proteins (see Figure 1A). The gene discussed is SKIL; the disease is melanoma.