Our data obtained in a large panel of melanoma cell lines suggest that SKI only marginally affects TGF-β signaling: slightly elevated basal expression of some of the classical TGF-β target genes, like PTHrP and IL-11, was observed in shSKI-transfected 1205Lu melanoma cells as compared to mock-transfected cells, yet SKI knockdown only marginally affected the response to TGF-β, as estimated both at the level of target gene transcription and cell proliferation. The gene discussed is PTHLH; the disease is melanoma.