TGF-β acts as a tumor suppressor by promoting cell cycle arrest or apoptosis of normal epithelial cells during early stages of carcinogenesis, while at later stages of tumorigenesis, it functions as a tumor promoter, inducing neoplastic cell invasiveness and metastasis through a process referred to as epithelial to mesenchymal transdifferentiation (EMT), and via modulation of the extracellular tumor microenvironment, production of chemokines and recruitment of immature bone marrow-derived myeloid cells to the invasive front of tumors, and inhibition of anti-tumoral immune defenses [4-8]. Here, TGFB1 is linked to neoplasm.