On the other hand, genes negatively correlated with OTF included Ogt, coding for a N-acetylglucosamine transferase enzyme activity implicated in heat-stress response [21], the mRNA splicing genes Hnrnpa2b1, a possible early detection marker of lung cancer [22], and Sfrs5 which is overexpressed in breast tumors [23]. This evidence concerns the gene SRSF5 and breast neoplasm.