Similarly in another study, we have demonstrated that inhibition of FOXO transcription factors by shRNA blocked resveratrol-induced upregulation of Bim, TRAIL, DR4, DR5, p27/Kip1 and apoptosis, and resveratrol-induced inhibition of cyclin D1 in prostate cancer cells in vitro[40]. The gene discussed is CCND1; the disease is prostate cancer.