Similarly in another study, we have demonstrated that inhibition of FOXO transcription factors by shRNA blocked resveratrol-induced upregulation of Bim, TRAIL, DR4, DR5, p27/Kip1 and apoptosis, and resveratrol-induced inhibition of cyclin D1 in prostate cancer cells in vitro[40]. This evidence concerns the gene TNFRSF10B and Familial prostate cancer.