In addition, the strength of the association of rs2066843 and rs2076756 with CD was less pronounced than that of the NOD2 variant rs2066847 (p.Leu1007fsX1008) which results in patients homozygous for this variant in a more severe phenotype [21], [22] than found for rs2066843 and rs2076756 in this study. Here, NOD2 is linked to Cowden disease.