Significant CD phenotype associations of rs2066843 and rs2076756 as shown in Tables 5, 6 and 7 stratified for the presence (NOD2+) or absence (NOD2-) of the three CD-associated NOD2 mutations p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847). This evidence concerns the gene NOD2 and Cowden disease.