Since genotype-phenotype analyses of the NOD2 variants p.Arg702Trp, p.Gly908Arg, and p.Leu1007fsX1008 have also provided strong evidence for the existence of a NOD2-related CD phenotype, these studies have not only changed our understanding of IBD pathogenesis but have also implications for clinical practice [21], [22], [23], [25]. This evidence concerns the gene NOD2 and Cowden disease.