Since the three common NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847) have been identified to be associated with a certain CD phenotype [21], [22], [23], [24], [30], we also performed a detailed genotype-phenotype correlation in IBD patients. The gene discussed is NOD2; the disease is inflammatory bowel disease.