NOD2 and Cowden disease: As shown in Table 8, there were no significant differences regarding homozygous carriers of these SNPs when stratified for the presence and absence of the main three CD-associated NOD2 variants and the significant phenotypic characteristics found in Tables 5, 6 and 7, suggesting that the CD-modifying effect of rs2066843 and rs2076756 is independent of the three main NOD2 variants.