Table 3&4). This is the first study to demonstrate the specificity of Ang-1 for CM in children, and we confirm and extend previous observations of elevated levels of VWFpp and VWF in children with severe malaria compared to non-malarial febrile illness [8]. Further, we show a marked and uniform decrease in Ang-2:Ang-1 at follow-up (Fig. 3), suggesting that the ratio between these two proteins may offer an approach to monitor clinical response. This evidence concerns the gene ANGPT2 and malaria.