Conversely, adenovirus mediated wild-type FLCN or FLCN/FNIP1 expression suppressed GPNMB mRNA expression more than 2 fold, but mutant FLCN (c.1285dupC, most frequent mutation in BHD syndrome), mutant FLCN/FNIP1 or FNIP1 alone did not suppress GPNMB expression in UOK257 cells (Fig. 1F). The gene discussed is GPNMB; the disease is Birt-Hogg-Dubé syndrome.