HIF1A and Familial prostate cancer: In addition to A431 vulvar squamous carcinoma cells, we found that 1, 9 PA could downregulate HIF-1α in PC3 prostate cancer cells, MDA468 breast cancer cells, MCF7 breast cancer cells transfected with a high level of HER2, and H3255 and HCC827 non-small cell lung cancer cells (Figure 1F).