This finding is in agreement with a recent report indicating that activation of syndecan-4 (SDC4), a transmembrane heparan sulfate proteoglycan that interacts with GIPC1 and the FGFR1 receptor to regulate FGF2 signaling, is required for cytokinesis of MCF-7 human breast cancer cells [32]. The gene discussed is FGF2; the disease is breast carcinoma.