GIPC1 and cancer: To further assess the assumption that GIPC1 plays a significant role in the development and progression of human cancers, 411 probesets with a fold-change ≥2 in SAM analysis of GIPC1 depleted MDA-MB231 cells compared to control cells (GIPC1 signature; Table S1) were used to interrogate two publicly available and clinically annotated breast and ovarian cancer datasets with the Bioconductor package, globaltest[27].