We observed over-expression of four major genes involved in the Wnt pathway, namely WNT5A, TCF7L2, MSX2 and TNFRSF11B. WNT5A encodes a major Wnt ligand affecting tumor cell motility and metastasis, but its role in breast cancer is controversial [23]. The gene discussed is TNFRSF11B; the disease is breast carcinoma.