Here, we confirm that the pseudogene CYP4Z2P is expressed in both PIK3CA-mutated and -non mutated ERα-positive breast tumors, by using specific primers unambiguously distinguishing CYP4Z2P from CYP4Z1. Thus, CYP4Z2P is transcriptionally active, but its translation remains to be studied. The gene discussed is PIK3CA; the disease is breast neoplasm.