Figure 1 panel A shows the frequency of HER2 positive tumors (2+ with gene amplification and 3+ score) with different hMena staining. Of interest, hMena is differently distributed within the four BC subtypes (p = 0.032). In fact, only 29% of the Luminal A and Luminal B subtypes overexpressed hMena with a score 3, whereas 48% and 44% of the HER2 and the Triple Negative subtypes, respectively showed hMena overexpression (Figure 1 panel B). Here, ERBB2 is linked to breast cancer.