VEGFA and ovarian hyperstimulation syndrome: This is the consequence of the longer halflife of hCG and affinity for the common receptor.[14] VEGF induces vascular hyperpermeability by interacting with its VEGF receptor 2 (VEGFR-2).[15, 16] Gómez et al.[17] showed that vascular permeability could be reduced by blocking VEGF receptor-2 and suggested that this approach could be used to prevent OHSS in humans.