PLOD1 and Infertility: For the last couple of decades, clomiphene citrate remained the most popular drug for ovulation induction at the initial stage of management of infertile couples with anovulation (WHO group II) and unexplained infertility.[1, 2] Though induction of ovulation was achieved in 42-80% cases depending on the diagnosis,[3] the conception rate averaged 9-13% per cycle through 3-6 cycle.[4, 5] The gap between ovulatory and pregnancy rates had variously been attributed to its anti-estrogenic effects on endometrium,[6] cervical mucous,[7] and high LH,[8] resulting in luteal phase dysfunction.