In recent years, the amount of cytotoxic agents and targeted therapies used to treat HNSCC, include classic chemotherapeutic agents, chemoprevention agents such as COX-2 inhibitors, monoclonal antibodies targeting tyrosine kinase receptors, small molecule tyrosine kinase inhibitors, and antiangiogenic drugs [90]. Here, PTGS2 is linked to head and neck squamous cell carcinoma.