NFKB1 and cancer: Mounting studies have reported that Sal-B is capable of preventing the development of cancer; and the possible antiinflammatory mechanisms of Sal-B involve modulating cytokines, Cyclooxygenase-2/prostaglandin E2 (COX-2/PGE-2) pathway [24, 25, 29], NF-κB [30–32], TNF-α [33–35] and MMPs [36–38].