INS and type 2 diabetes mellitus: When participants were stratified by low and high insulin level groups (median = 99 pmol/l), the association of HNF1A G319S with incident type 2 diabetes remained significant in both groups although the association in the low insulin group was stronger compared to the high insulin group (OR 6.96 [95% CI 2.73-17.72] and 2.53 [1.14-5.60], respectively).