With adjustment for age, sex, hypertension, triglyceride, waist circumference, and HDL cholesterol, the association of the HNF1A polymorphism with 10-year changes in fasting glucose remained significant (beta = 0.645, SE = 0.257, p = 0.01), while the association with 10-year changes in 2-hour postload glucose was attenuated to non-significance (beta = 0.880, SE = 0.470, p = 0.06). This evidence concerns the gene HNF1A and hypertensive disorder.