Interestingly, median circulating FGF-21 level was 3-fold higher in CHD patients (513.5±47.5 ng/l) compared with control subjects (167.9±15.6 ng/l) (P<0.0001) after adjusted for body mass index (BMI) (Table 1 and Figure 1A). This evidence concerns the gene FGF21 and coronary artery disorder.