Stepwise logistic regression analysis revealed that ApoA1 (β coefficient −0.304, 95% CI −0.500 to –0.173, P<0.001), fasting glucose (β coefficient 0.219, 95% CI 0.013 to 0.087, P = 0.008) and triglyceride (β coefficient 0.213, 95% CI 0.016–0.124, P = 0.011) independently associated with serum FGF-21 after adjustment for BMI, diabetes and hypertension. The gene discussed is FGF21; the disease is Hypertension.