Furthermore, serum FGF-21 levels in CHD patients with both diabetes and hypertension (502.3 ng/l, [157.6–2614.9], n = 45) were significantly higher than that of CHD patients without diabetes and hypertension (410.5 ng/l, [77.8–1069.2], n = 21, p = 0.026, Figure 1D). This evidence concerns the gene FGF21 and diabetes mellitus.