PPIB and thalassemia: The four different β thalassemia mutations found in the present study were broadly similar to the distribution observed in Indians.[13] Among these, IVS 1-5 (G→C), a severe β+ thalassemia allele was found to be the commonest, followed by codon 15 (G→A), codon 30 (G→C) and codon 8/9 (+G) which are severe β0 thalassemia alleles.