CASP8 and cancer: In recent years, genetic variants in caspase mediated apoptosis and their role in human cancer susceptibility have been getting more and more attention, especially the apoptosis initiator caspase 8.[6] Therefore, this study was undertaken to test Caspase 8 IVS12-19 G>A, Caspase 8D302H G>C, Caspase 8 -652 6Ndel and Caspase 8 -678_-673del polymorphisms in North Indian healthy population.