IGHE and asthma: Earlier, it was found that homozygous Gly-16 was associated with a more severe asthma phenotype,[14] but this has not been supported by more recent studies.[15] Gly-16 has also been associated with nocturnal asthma[16] and in children it has been reported to be associated with decreased bronchodilator response to an inhaled β-2 agonist.[17] The Glu-27 polymorphism has been reported to be associated with decreased airway reactivity in asthma.[18] The Gln-27 allele, on the other hand, has been associated with elevated IgE levels and an increase in self-reported asthma in children.