Those with variant LTC4 synthase genotype (C/C or C/A genotype, n = 13) had a 9% increase in FEV1, whereas patients with the wild type (A/A genotype, n = 10) had a 12% decrease.[36] This polymorphism also shows an association with aspirin induced asthma and also contributes to increased LTC4 in the airway.[37] It is also considered as a potential risk factor for adverse reactions to nonsteroidal analgesics in asthma. Here, LTC4S is linked to asthma.