Intradialytic aerobic exercise has been shown to be safe in the first 2 h of dialysis; after 2 h, cardiac decompensation may occur.[26] Furthermore, intradialytic cycling improves hematocrit levels, peak oxygen consumption, quality of life, dialysis efficacy, and physical functioning,[15, 27] while interdialytic aerobic training on nondialysis days improves quality of life, lipid profile, anemia, and insulin sensitivity,[28, 29] and decreases anxiety-depression disorders.[30]. This evidence concerns the gene INS and depressive disorder.