Brunt et al. reported that hypertension improved in 92% of patients after laparoscopic adrenalectomy, but 69% of them still required medication.[26] Generally, the risk factors for persistent hypertension are the presence of hypertension on discharge from hospital, the response to spironolactone, a long preoperative duration of hypertension, and a high preoperative plasma renin activity. The gene discussed is REN; the disease is hypertensive disorder.