In Parkinson’s disease dopamine (D2) receptors in the basal ganglia and substantia nigra facilitate detrusor activity, whereas the D1 receptor facilitates micturition.[60] When drug administered to Parkinson’s patients, dopaminergic drug improves bladder activity but might worsen neurogenic detrusor overactivity and urge incontinence. This evidence concerns the gene DRD2 and Parkinson disease.