GABBR1 and overactive bladder: GABA-B receptor agonists are beneficial in the treatment of overactive bladder.[55] Baclofen, a GABA-B receptor subtype agonist, inhibits reflex activation of motor neurons.[56] Baclofen does not affect the response to stimulation of electrical field or muscarinic receptors of human detrusor strips[57] but some reduction in the nerve-mediated response occurred, with baclofen acting via.