In human tissue samples, accumulating evidence indicates that MRP2 expression is also associated with intrinsic CDDP resistance in the clinical setting, using tissues obtained from patients with colorectal cancer (Hinoshita et al, 2000), small-cell lung carcinoma (Ushijima et al, 2007), and ovarian cancer (Surowiak et al, 2006). This evidence concerns the gene ABCC2 and small cell lung carcinoma.