ABCC2 and cancer: Interestingly, several cisplatin (CDDP)-resistant human cancer cell lines overexpress MRP2, including ovarian cancer, hepatocellular carcinoma, bladder cancer, and colon cancer (Taniguchi et al, 1996; Kool et al, 1997; Liedert et al, 2003; Materna et al, 2005).