In addition, a significant positive correlation between expression of p300 and Ki67 was evaluated in our HCC cohort, in which the frequency of cases with high expression of Ki67 was significantly larger in carcinomas with a high expression of p300 (32/56 cases, 57.1%) than in those cases with a low expression of p300 (18/62 cases, 29.0%) (P = 0.002, Table 1). Here, EP300 is linked to hepatocellular carcinoma.