In addition, the treatment with the DNA hypomethylating agent 5-aza-2’-deoxycytidine was able to induce a de novo expression of MAGE-A3, MAGE-A4, GAGE 1-2, GAGE 1-6 and SSX 1-5 in both ABCG2+ and ABCG2- IGR37 melanoma cells (Table 5). The gene discussed is ABCG2; the disease is melanoma.