The decrease in caspase activation observed after Praf2 RNAi was not apoptotic stimulus-specific nor cell type-specific, as it was evident also in U2OS cells treated with paclitaxel or doxorubicin (Fig. S2A) and in the breast cancer cell line MDA-MB 231 treated with etoposide (Fig. S2B). The gene discussed is PRAF2; the disease is breast cancer.