T8 and T8.2 (Vβ8.1,8.2+) lymphoma cells, but not T14 (Vβ14+) and T5 (Vβ5+) neoplastic cells, strongly proliferated in vitro in the presence of SEB which interacts with the Vβ8 family of mouse TCRs. This evidence concerns the gene SETBP1 and lymphoma.