Our recent data[20] demonstrated that nuclear RB1CC1 forms a large transcriptional complex with hSNF5, p53 and/or PIASy that activates a global transcription of genes (RB1, p16 and p21) involved in the RB1 pathway—indicating a possible linkage to mitotic senescence—and suppresses tumor cell growth. The gene discussed is RB1CC1; the disease is neoplasm.