In contrast, melanocytes infected with BRAF600E and with shATF2 formed on average about 20 colonies, indicative of loss of tumorigenicity (Figure 6b, 6c, 6d) and consistent with our initial observation that the number of melanoma tumors significantly decreases in the absence of transcriptionally functional ATF2 (Tables 1–2). This evidence concerns the gene ATF2 and melanoma.