HMVEC-d cells infected with KSHV induced rapid tyrosine phosphorylation of c-Cbl, which was detectable as early as 1 min post-infection (p.i.), reaching maximum levels at 5 min (4.1-fold), followed by a decrease which was constent for as much as 30 min p.i. (Figure 1a). The gene discussed is CBL; the disease is infection.