Lungs of Puma+/+ mice demonstrated modest intra-alveolar inflammation with preservation of lung architecture (Figure 2, A and B), while Puma−/− mice exhibited fibrinopurulent pleuritis, extensive consolidation and loss of alveolar integrity with several mice demonstrating an accumulation of leukocytes and bacteria in prominent abscesses (Figure 2, E and F). This evidence concerns the gene BBC3 and Pleuritis.