Thus, the autocrine and paracrine hematopoietic and inflammatory effects of Spz are amplified in the presence of hyperactive Toll receptor, excessive Dorsal/Dif, or the loss of Cactus/Ubc9 inhibition, resulting in production of hematopoietic tumors [18], [29]. The gene discussed is UBE2I; the disease is hematopoietic and lymphoid cell neoplasm.