However, although the TLR5 risk haplotype (ACC) on its own without the two TLR4 SNPs was significantly associated with IBD (p = 0.029), a haplotype combination containing the two associated TLR4 SNPs without the associated TLR5 risk haplotype (ACC) was not statistically associated with IBD (p = 0.67). The gene discussed is TLR4; the disease is inflammatory bowel disease.