CD4 and infection: Unsurprisingly, quite a number of researchers has pointed to the early infection period around the peaking of viremia, prior to massive CD4 T cell destruction and the establishment of viral reservoirs, as a narrow but crucial period in which the antiretroviral therapy can secure a certain advantage on the virus, controlling its replication, preventing extensive CD4 T cell depletion from occurring, and curbing generalized immune activation [2], [3].