MAPK3 and neoplasm: In susceptible cell lines from several different cancer types, activation of CB receptors leads to a variety of different cellular events, including the sustained production of ceramide, reduced expression of vascular endothelial growth factor and matrix metalloprotease-2, and the sustained activation of extracellular signal-related kinase 1/2, resulting in apoptosis, inhibition of tumour adhesion, migration and angiogenesis [2], [23], [24].