Extrapolating this finding to the prostate (with all the appropriate caveats concerning different cancer cell types and the large step between cultured cells and tumour tissue), it can be argued that overexpression of EGFR ligands, the EGFR receptor itself, and/or the level of EGFR activation would work against the local protective endocannabinoid tone. The gene discussed is EGFR; the disease is neoplasm.