SERPINE1 and Insulin resistance: These and other proteins (i.e. ASP, MPO, PAI-1 and VEGF) included in this cluster and in cluster 1 that was associated with insulin were previously found to be increased in subjects with insulin resistance, CVD, or both [3], [21], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32].