We previously reported that a fusion protein containing ODD548–603 of human HIF-1α is efficiently degraded under normoxic conditions through a pVHL-mediated protein degradation system as HIF-1α [7] and that a fusion protein PTD-ODD548–603-procaspase-3 significantly increased caspase-3 activity and selectively induced apoptosis in HIF-active/hypoxic cancer cells in vitro and in vivo[7]-[12]. This evidence concerns the gene HIF1A and cancer.