Compared to previous studies in MM in which only a fraction of primary tumors expressed Hh pathway components [6], [23] a high proportion of the primary B-ALL specimens (39/41, 95%) expressed all three genes PTCH1, SMO and GLI1 (noted as “Hh pathway expression” in Table 1). Here, PTCH1 is linked to precursor B-cell acute lymphoblastic leukemia.