CSC have been reported in B-ALL, but a universal phenotype has not been described and is likely to vary according to the specific B-ALL subtype.16–21 Tumorigenic cells have been identified using specific surface antigen expression in most diseases, but stem cells may be isolated from normal tissues based on processes conferring drug resistance such as ABCG2 and aldehyde dehydrogenase (ALDH) [24]–[26]. Here, ABCG2 is linked to precursor B-cell acute lymphoblastic leukemia.