In a recent report, Koptyra et al observed higher levels of FANCD2 monoubiquitination in cells from CML patients and also in BCR/ABL-transformed cells, compared to wild type cells, and proposed that this effect could play a role in BCR/ABL leukemogenesis[44]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.