LARGE1 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: None of the other enzymes responsible for dystroglycanopathies has a similar effect; however we have previously demonstrated that the overexpression of the LARGE paralog GYLTL1B (or LARGE2) is equally capable of hyperglycosylating α-DG in cultured cells [29], [31], [33]; mutations in this gene have not yet been associated with a human pathology.