Cardiomyocyte controls expressed several genes coding for growth factors which could be candidate genes for the unknown factor secreted by cardiomyocytes, which might include connective tissue growth factor (Ccn2/Ctgf), insulin-like growth factor 1 and 2 (Igf-1, 2) and Tgfb1. TGFB1 has been shown to up-regulate the Tgfb2 gene in a pancreatic cancer cell line [33]. Here, IGF1 is linked to familial pancreatic carcinoma.