For example, the response against hepatitis C virus infection is mediated by the TLR2 and TLR3 signaling [30], [31], while West Nile Virus (WNV) can be recognized by TLR-3, eliciting an antiviral response shaping innate as well as adaptive immunity in in vivo experiments [32], [33]. This evidence concerns the gene TLR3 and hepatitis C virus infection.