This study found that the levels of cleaved CK-18 (M30 antigen), and intact CK-18 (M65) predicted histological NASH with 70% sensitivity, 84% specificity, AUROC 0.711 and 64% sensitivity, 89% specificity and AUROC 0.814 respectively. This evidence concerns the gene KRT18 and metabolic dysfunction-associated steatohepatitis.