Interleukin-6 (IL-6) is another marker of inflammation which has been shown to be elevated in NASH.121 In a study comparing 43 NASH patients, 40 subjects with steatosis and 48 controls, normal levels of IL-6 were highly specific in confirming the absence of NASH, with an AUROC of 0.817 for distinguishing NASH from simple steatosis. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.