In this study, the combination of serum adiponectin level with HOMA-IR and type IV collagen 7S demonstrated a sensitivity of 94% and specificity of 74% for diagnosing NASH.114 Hui et al. also reported significantly lower adiponectin levels and higher HOMA-IR in patients with NASH compared with subjects with simple steatosis, and demonstrated an AUROC of 0.79 for the combination of these markers for distinguishing between steatohepatitis and steatosis.115 However, the relationship between adiponectin levels and severity of hepatic fibrosis remains to be established.116, 117. This evidence concerns the gene ADIPOQ and Hepatic fibrosis.