Thioredoxin (TRX) is stress-inducible thiol-containing protein which may represent a clinically useful indicator of oxidative stress.127 In a small study of 57 patients, Sumida et al. demonstrated significantly elevated serum TRX levels in patients with NASH compared with those with simple steatosis and healthy controls, with an AUROC of 0.785 for distinguishing NASH from simple steatosis.127 Similar findings have been reported elsewhere, with a correlation between serum TRX and ferritin levels also observed.128. The gene discussed is TXN; the disease is metabolic dysfunction-associated steatohepatitis.